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ZymoGenetics inc i.v. ril-21
I.V. Ril 21, supplied by ZymoGenetics inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ril-21/ril+21/pmc11024325-0-20-23
Average 90 stars, based on 1 article reviews
i.v. ril-21 - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Therapeutic potential of interleukin-21 in cancer
Article Snippet: NCT00389285 , 1/2 , 2006 Completed , Metastatic renal cell carcinoma , Safety study of i.v. rIL-21 in combination with VEGFR tyrosine kinase inhibitor sorafenib , ZymoGenetics, United States , ( ) .

Article Title: IFN-gamma-mediated inhibition of human IgE synthesis by IL-21 is associated with a polymorphism in the IL-21R gene.
Article Snippet: Stimulation of B cells for proliferative responses or induction of Ig production was conducted as follows: naive or memory CD19 human B lymphocytes (106/ml) were cultured with 1 g/ml anti-CD40 mAb 89 (17), in the presence or absence of combinations of rIL-4 (gifts from Dr. F. Brière, Schering-Plough, Dardilly, France) and rIL-21 (a gift from Dr. D. Foster, Zymogenetics, Seattle, WA) in flat-bottom 96-well culture plates (Nunc) in Yssel’s medium (18), supplemented with 10% FCS in sextuplate in a final volume of 200 l. PBMC (106/ml) were cultured with the same combinations of cytokines, in the presence or the absence of the anti-CD40 mAb.

Article Title: Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins.
Article Snippet: Purpose Recombinant interleukin-21 (rIL-21) is an immune stimulating cytokine recently tested in two Phase 1 trials for immune responsive cancers.. A secondary objective of these trials was to characterize pharmacodynamic responses to rIL-21 in patients.. Here, we report the eVects of systemic rIL-21 on serum markers of immune stimulation.

Article Title: An Open-Label, Two-Arm, Phase I Trial of Recombinant Human Interleukin-21 in Patients with Metastatic Melanoma
Article Snippet: These were chosen because they are similar to schedules commonly used for cytokine therapy with IL-2 or IFN-a. rIL-21 is being developed by both ZymoGenetics, Inc. and Novo Nordisk A/S.

Article Title: Therapeutic potential of interleukin-21 in cancer
Article Snippet: NCT00347971 , 1 , 2006 Completed , non-Hodgkin’s lymphoma , Safety study of i.v. rIL-21 in combination with anti-CD20 mAb rituximab (rituxan) , ZymoGenetics, United States , ( ) .

Article Title: Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins
Article Snippet: Based on the biologic effects demonstrated in preclinical models, rIL-21 is being developed by ZymoGenetics, Inc. and Novo Nordisk A/S as a potential immunotherapeutic agent for cancer indications.

Article Title: Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma.
Article Snippet: presented at 7th World Melanoma congress; May 2009 •• Phase II study with rIL-21 in chemotherapy naive metastatic or recurrent melanoma patients.. 47.. Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma.



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Clinical trials of interleukin-21 in cancer immunotherapy.

Journal: Frontiers in Immunology

Article Title: Therapeutic potential of interleukin-21 in cancer

doi: 10.3389/fimmu.2024.1369743

Figure Lengend Snippet: Clinical trials of interleukin-21 in cancer immunotherapy.

Article Snippet: NCT00523380 , 2 , 2007 Completed , Ovarian Cancer , Efficacy study of i.v. rIL-21 (NN028) in combination with Caelyx (pegylated liposomal doxorubicin) , Novo Nordisk A/S, France and Germany , No publications available.

Techniques: Clinical Proteomics, Comparison, Drug discovery, Recombinant, Virus, Injection